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CHRONOBIOLOGY AND CHRONOTHERAPY OF AFFECTIVE DISORDERS

Andrew N. COOGAN*
National University of Ireland Maynooth, Maynooth, Ireland

Abstract
Circadian rhythms are recurring cycles across a range of behavioural, physiological and cognitive domains that display periods of approximately twenty four hours and are generated by an endogenous circadian timing system. In this review we examine the evidence that circadian rhythms are disrupted in affective disorders such as major depression, bipolar disorder and seasonal affective disorder, and examine what the nature of  circadian dysfunction may be. Further, we examine the evidence that chronotherapeutic interventions (both behavioural and pharmacological) that address underlying abnormalities of circadian phase in patients with affective disorders may produce rapid onset and long-lasting symptom relief. We conclude that there is promising data in the literature to support the utility of drawing on a considerable body of neuroscientific knowledge of circadian clock fundamentals to design and implement chronotherapeutic interventions in major affective disorders, but that there is also a need for a more systematic approach involving larger scale studies.

Keywords: Circadian, affective, chronotherapy, depression, bipolar, sleep

Jul 25, 2014admin
INTERNET-ADMINISTERED COGNITIVE-BEHAVIORAL THERAPY FOR INSOMNIAEXECUTIVE FUNCTIONING DIFFICULTIES AND DEPRESSION SYMPTOMS: MULTIDIMENSIONAL ASSESSMENT, INCREMENTAL VALIDITY, AND PROSPECTIVE ASSOCIATIONS
Journal of Evidence-Based Psychotherapies

Journal of Evidence-Based Psychotherapies

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Keywords
irrational beliefscbtrebtEditorialdistresscognitive-behavioral therapyappraisalcognitive restructuringschemasautism spectrum disordersbinary model of distressrational emotive behavior theoryconversion disorderautismhypnosispositive illusionstheory of mindearly interventioncommunicationdevelopmentthe Attitudes and Belief Scale 2incompatible information techniquedeficitsneural structurestoddlerscognitive psychologyrational anticipation techniquewithdrawal motivational systemsattributionsfunctional and dysfunctional negative emotionsunitary model of distressmind reading beliefsirrational and rational beliefstreatmenteating behavioursmental healtharousalpre-goal/ post-goal attainment positive emotionsfunctional and dysfunctional emotionscore relational themesapproach motivational systemsdemandingnessdysfunctional consequencesdysfunctional positive emotionspreferences
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